Health Library Logo

Health Library

Leiomyosarcoma

Overview

Leiomyosarcoma is a uncommon type of cancer. It starts in the smooth muscle, which is found in many parts of the body. This includes the organs of the digestive system, like the stomach and intestines, the urinary system, blood vessels, and the uterus.

Most often, leiomyosarcoma begins in the smooth muscle of the uterus, abdomen (belly), or legs. It starts as a lump of abnormal cells. This type of cancer can grow quickly and sometimes spread to other parts of the body.

The symptoms of leiomyosarcoma vary depending on where it develops. In the early stages, there might not be any noticeable symptoms. This is why early detection is so important.

Leiomyosarcoma is a kind of soft tissue sarcoma. Soft tissue sarcomas are a group of cancers that begin in the tissues that connect, support, and surround other parts of the body. Think of these tissues as the "glue" and "scaffolding" that holds everything together. Examples include tendons, ligaments, fat, and muscle.

Symptoms

Leiomyosarcoma, a type of cancer, can sometimes not show any noticeable problems at first. However, as the cancer grows, you might experience some signs and symptoms. These can include:

  • Pain: This pain could be anywhere, depending on where the cancer is growing.
  • Weight loss: This often happens because the cancer uses up energy and nutrients from the body.
  • Nausea and vomiting: These are common symptoms of many illnesses, including some cancers.
  • A lump or swelling under the skin: This is a visible sign that something might be wrong and could be a telltale sign of a tumor.

If you have any of these or other symptoms that worry you, it's important to see a doctor or other healthcare provider right away. Early detection and treatment are crucial for managing any health concern.

When to see a doctor

If you're feeling unwell and concerned about your symptoms, it's important to schedule a visit with a doctor or other healthcare provider. This could be a family doctor, a specialist, or a nurse practitioner. Don't ignore symptoms that bother you; getting professional medical attention is a good way to get the right care and address any health issues early.

Causes

Leiomyosarcoma is a type of cancer that starts in the smooth muscles of the body. Smooth muscle is found in many parts of the body, such as the digestive tract, bladder, blood vessels, and uterus. We don't fully understand what causes these changes, but it likely involves something going wrong with the cells' DNA.

DNA is like a set of instructions for a cell. In healthy cells, DNA tells the cells how fast to grow and divide, and when to die. This controlled process keeps things balanced.

In leiomyosarcoma, the DNA instructions are altered. These altered instructions tell the cells to grow and multiply much faster than they should, and they ignore the signals to die. This uncontrolled growth leads to a buildup of abnormal cells.

These extra cells can form a lump, or tumor, that can grow and spread into nearby healthy tissue. Over time, some cancer cells might break off and travel through the bloodstream or lymphatic system to other parts of the body. When cancer spreads like this, it's called metastatic cancer.

Risk factors

Leiomyosarcoma is a type of cancer. Understanding the factors that increase the chance of getting it can help people. While doctors don't know how to prevent it, they do know some things that might make a person more likely to develop this cancer.

One risk factor is age. Leiomyosarcoma can occur at any age, but it's more common in adults than children. It's not very common in children.

Another risk factor is certain genetic conditions. Some people with specific genetic problems, like hereditary retinoblastoma or Li-Fraumeni syndrome, have a higher chance of developing leiomyosarcoma. These conditions can affect how a person's cells grow and function, which can increase the risk of cancer.

Currently, there's no known way to prevent leiomyosarcoma. Doctors are still researching to find ways to lower the risk.

Diagnosis

Doctors use several methods to diagnose leiomyosarcoma, a type of cancer. First, they'll ask about your symptoms and medical history, and do a physical exam. This involves checking for any unusual lumps or swelling.

To get a better understanding of the cancer, doctors use imaging tests. These tests create pictures of the inside of your body. Common imaging tests for leiomyosarcoma include:

  • MRI (Magnetic Resonance Imaging): This test uses magnets and radio waves to create detailed images.
  • CT (Computed Tomography) Scan: This test uses X-rays to create cross-sectional images of the body.
  • PET (Positron Emission Tomography) Scan: This test uses a radioactive substance to show areas of high activity in the body, which can help pinpoint the cancer.

Another important step is a biopsy. A biopsy is where a small piece of tissue is removed and sent to a lab for testing. The exact method depends on where the cancer is located. For leiomyosarcoma, a needle biopsy is often used. A doctor inserts a thin needle through the skin to collect a tissue sample.

The lab analyzes the tissue sample to see if cancer cells are present. The results will help determine if it's leiomyosarcoma and the extent of the cancer.

Crucially, a biopsy for leiomyosarcoma needs to be done carefully to avoid complications during any future surgery. It's important to get this type of biopsy from a medical center with a lot of experience treating this specific cancer. Experienced doctors and specialists can choose the best biopsy method, minimizing risks and maximizing the chance of accurate results.

Treatment

Treating Leiomyosarcoma: A Personalized Approach

Leiomyosarcoma treatment is tailored to the specific situation. Factors like the cancer's location, size, and whether it's spread to other parts of the body are crucial. Your overall health and your preferences also play a role in deciding the best course of action.

Surgery: The goal of surgery is to completely remove the leiomyosarcoma. However, if the cancer is large or close to vital organs, it might not be possible to remove it all. In these cases, the surgeon will aim to remove as much of the tumor as safely possible.

Radiation Therapy: This treatment uses powerful energy beams, like X-rays or protons, to target and destroy cancer cells. Radiation can be used before, during, or after surgery. It's helpful for cancer cells that can't be removed surgically or when surgery isn't an option at all.

Chemotherapy: This approach uses strong medications to kill cancer cells. These drugs are usually given through an IV (into a vein). Chemotherapy might be used to prevent the cancer from returning after surgery or to control the spread of the disease to other parts of the body.

Targeted Therapy: This type of treatment uses special drugs that target specific molecules within cancer cells. By disrupting these molecules, targeted therapies can cause the cancer cells to die. This approach might be considered if the leiomyosarcoma is large or has spread. Your doctor may test your cancer cells to see if targeted therapies could be effective.

Managing Your Well-being: Dealing with a cancer diagnosis is a significant challenge. It's important to take care of yourself emotionally and practically. Here are some helpful strategies:

  • Ask Questions: Talk to your healthcare team about your cancer, test results, treatment options, and your prognosis (the likely outcome). Understanding these details empowers you to make informed decisions about your care.

  • Nurture Your Relationships: Strong relationships with family and friends can provide vital support. They can offer practical help, like taking care of household tasks, or emotional support when you're feeling overwhelmed.

  • Find a Support System: Talk to someone about your hopes and fears. This could be a friend, family member, counselor, medical social worker, clergy member, or a support group. Support groups can connect you with others facing similar challenges and offer a sense of community. The National Cancer Institute and the American Cancer Society are valuable resources for information and support in the United States.

By understanding your treatment options and actively seeking support, you can navigate the challenges of leiomyosarcoma and focus on your well-being.

Address: 506/507, 1st Main Rd, Murugeshpalya, K R Garden, Bengaluru, Karnataka 560075

Disclaimer: August is a health information platform and its responses don't constitute medical advise. Always consult with a licenced medical professional near you before making any changes.

Made in India, for the world