Ramucirumab (intravenous route)

Cyramza

Ramucirumab injection is used alone or together with paclitaxel to treat advanced or metastatic (cancer that has already spread) stomach or gastroesophageal junction cancer (GEJ) after a patient has received other cancer medicines (eg, medicines that containing fluoropyrimidine or platinum) but did not work well. Ramucirumab injection is also together with erlotinib used as first-line treatment for metastatic (cancer that has already spread) non-small cell lung cancer (NSCLC) in patients who have certain types of abnormal epidermal growth factor receptor (EGFR) gene (exon 19 deletions or exon 21 mutations). Your doctor will perform a test before you take this medicine. Ramucirumab injection is also used in combination with docetaxel to treat metastatic (cancer that has already spread) non-small cell lung cancer (NSCLC) in patients who have received other cancer medicines (eg, medicines containing platinum). It is given to patients whose tumors have an abnormal EGFR or ALK gene and have tried treatment for these tumors but did not work well. Ramucirumab injection is also used in combination with folinic acid, 5-fluorouracil, and irinotecan (FOLFIRI) to treat metastatic (cancer that has already spread) colorectal cancer (mCRC) in patients who have received other cancer medicines (eg, bevacizumab, oxaliplatin, or medicines containing fluoropyrimidine) but did not work well. Ramucirumab injection is also used to treat a type of liver cancer called hepatocellular carcinoma (HCC) in patients who have received other medicines (eg, sorafenib). This medicine is to be given only by or under the direct supervision of your doctor. This product is available in the following dosage forms:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of ramucirumab injection in the pediatric population. Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ramucirumab injection in the elderly. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: